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  • Background articles
  • SPPB utilization examples
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additional references

Examples of Studies Using the SPPB - Click on Title to go to Abstract in PubMed

General methodological papers


  • Measuring physical capacity and performance in older people. Lamb SE, Keene DJ. Best Pract Res Clin Rheumatol. 2017 Apr;31(2):243-254. doi: 10.1016/j.berh.2017.11.008. Epub 2017 Nov 22. Review. PMID: 29224699
  • Measuring frailty in clinical practice: a comparison of physical frailty assessment methods in a geriatric out-patient clinic. Pritchard JM, Kennedy CC, Karampatos S, Ioannidis G, Misiaszek B, Marr S, Patterson C, Woo T, Papaioannou A. BMC Geriatr. 2017 Nov 13;17(1):264. doi: 10.1186/s12877-017-0623-0. PMID29132301


Observational studies


  • Comparison of Muscle Mass Indices Using Computed Tomography or Dual X-Ray Absorptiometry for Predicting Physical Performance in Hemodialysis Patients. Kang SH, Lee HS, Lee S, Cho JH, Kim JC. Kidney Blood Press Res. 2017 Dec 7;42(6):1119-1127. doi: 10.1159/000485779. [Epub ahead of print] PMID: 29224021
  • Fear of falling predicts incidence of functional disability two years later: A perspective from an international cohort study.  Auais M, French S, Alvarado B, Pirkle C, Belanger E, Guralnik J. J Gerontol A Biol Sci Med Sci. 2017 Dec 6. doi: 10.1093/gerona/glx237. [Epub ahead of print] PMID: 29220420
  • Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia. Klepin HD, Tooze JA, Pardee TS, Ellis LR, Berenzon D, Mihalko SL, Danhauer SC, Rao AV, Wildes TM, Williamson JD, Powell BL, Kritchevsky SB. J Am Geriatr Soc. 2016 Oct;64(10):1988-1995. doi: 10.1111/jgs.14301. Epub 2016 Sep 14. PMID: 27627675


SPPB used to screen for study eligibility


  • Effects of Acute Phase Intensive Electrical Muscle Stimulation in Frail Elderly Patients With Acute Heart Failure (ACTIVE-EMS): Rationale and protocol for a multicenter randomized controlled trial. Tanaka S, Kamiya K, Matsue Y, Yonezawa R, Saito H, Hamazaki N, Matsuzawa R, Nozaki K, Wakaume K, Endo Y, Maekawa E, Yamaoka-Tojo M, Shiono T, Inomata T, Masuda T, Ako J. Clin Cardiol. 2017 Dec 16. doi: 10.1002/clc.22845. [Epub ahead of print] PMID: 29247531
  • Development of a Novel Six-Month Nutrition Intervention for a Randomized Trial in Older Men with Mobility Limitations. Apovian CM, Singer MR, Campbell WW, Bhasin S, McCarthy AC, Shah M, Basaria S, Moore LL. J Nutr Health Aging. 2017;21(10):1081-1088. doi: 10.1007/s12603-017-0990-4. PMID: 29188864


SPPB used as an outcome in an RCT


  • Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. LIFE Study Investigators, Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1157-65. Erratum in: J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):337.  PMID: 17167156
  • Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Prestmo A, Hagen G, Sletvold O, Helbostad JL, Thingstad P, Taraldsen K, Lydersen S, Halsteinli V, Saltnes T, Lamb SE, Johnsen LG, Saltvedt I. Lancet. 2015 Apr 25;385(9978):1623-33. doi: 10.1016/S0140-6736(14)62409-0. Epub 2015 Feb 5 PMID: 25662415
  • Effect of a home-based exercise program on functional recovery following rehabilitation after hip fracture: a randomized clinical trial. Latham NK, Harris BA, Bean JF, Heeren T, Goodyear C, Zawacki S, Heislein DM, Mustafa J, Pardasaney P, Giorgetti M, Holt N, Goehring L, Jette AM. JAMA. 2014 Feb 19;311(7):700-8. doi: 10.1001/jama.2014.469. PMID: 24549550
  • A tailored counseling and home-based rehabilitation program to increase physical activity and improve mobility among community-dwelling older people after hospitalization: protocol of a randomized controlled trial. Turunen K, Aaltonen L, Kumpumäki J, Portegijs E, Keikkala S, Kinnunen ML, Finni T, Sipilä S, Nikander R. BMC Musculoskelet Disord. 2017 Nov 21;18(1):477. doi: 10.1186/s12891-017-1825-5. PMID: 29162078
  • Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial. Layne AS, Krehbiel LM, Mankowski RT, Anton SD, Leeuwenburgh C, Pahor M, Sandesara B, Wu SS, Buford TW. Contemp Clin Trials Commun. 2017 Jun;6:58-63. doi: 10.1016/j.conctc.2017.03.002. Epub 2017 Mar 18. PMID: 28944303
  • Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial. Fielding RA, Guralnik JM, King AC, Pahor M, McDermott MM, Tudor-Locke C, Manini TM, Glynn NW, Marsh AP, Axtell RS, Hsu FC, Rejeski WJ; LIFE study group. PLoS One. 2017 Aug 18;12(8):e0182155. doi: 10.1371/journal.pone.0182155. eCollection 2017. PMID: 28820909
  • Physical Rehabilitation for Older Patients Hospitalized for Heart Failure.  Kitzman DW ,  Whellan DJ, Duncan P, Pastva AM, Mentz RJ , Reeves GR,  Nelson MB , Chen H,  Upadhya B, Reed SD,  Espeland MA, Hewston LA, O'Connor CM. N Engl J Med. 2021 May 16. doi: 10.1056/NEJMoa2026141. Online ahead of print. PMID: 33999544 

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